This Order amends the National Institute for Clinical Excellence (Establishment and Constitution) Order 1999 to change the name of the Institute to the National Institute for Health and Clinical Excellence (article 2), to give the Institute additional functions (article 3), to increase the number of members of the Institute who are not officers from eight to not less than eight but not more than ten, to increase the number of members who are officers of the Institute from five to six and to change the office of Clinical Director to that of the Director of Clinical and Public Health and to provide that one of the officer members shall be the Director of Health Improvement (article 4).